| Date | H/A | W/L | Team | Score | Opponent | Score | |||
| 2021-12-07 | A | L | Oak Glen | 53 | Weir | 54 | 485 | ||
| 2021-12-10 | H | L | Oak Glen | 40 | John Marshall | 58 | 377 | ||
| 2021-12-14 | H | L | Oak Glen | 47 | Brooke | 72 | 378 | ||
| 2021-12-18 | H | W | Oak Glen | 62 | Toronto (OH) | 46 | 613 | ||
| 2021-12-21 | H | L | Oak Glen | 56 | Wellsville (OH) | 66 | 379 | ||
| 2021-12-28 | A | L | Oak Glen | 39 | Madonna | 59 | 339 | ||
| 2022-01-04 | H | L | Oak Glen | 40 | Beaver Local (OH) | 49 | 1335 | ||
| 2022-01-07 | A | L | Oak Glen | 44 | Wheeling Central | 62 | 1345 | ||
| 2022-01-10 | A | L | Oak Glen | 47 | North Marion | 76 | 1331 | ||
| 2022-01-14 | H | W | Oak Glen | 61 | Steubenville Central (OH) | 48 | 1337 | ||
| 2022-01-15 | A | W | Oak Glen | 62 | Wellsville (OH) | 59 | 1338 | ||
| 2022-01-18 | H | L | Oak Glen | 58 | Weir | 67 | 1339 | ||
| 2022-01-21 | A | L | Oak Glen | 42 | Wheeling Central | 65 | 1346 | ||
| 2022-01-26 | H | L | Oak Glen | 52 | Madonna | 67 | 380 | ||
| 2022-02-01 | H | L | Oak Glen | 41 | East Liverpool (OH) | 71 | 1340 | ||
| 2022-02-02 | A | L | Oak Glen | 50 | Brooke | 78 | 46 | ||
| 2022-02-05 | A | W | Oak Glen | 50 | Steubenville Central (OH) | 48 | 1344 | ||
| 2022-02-08 | H | W | Oak Glen | 64 | Toronto (OH) | 57 | OVAC Consolation | 1626 | |
| 2022-02-10 | A | L | Oak Glen | 58 | Beaver Local (OH) | 63 | 1659 | ||
| 2022-02-11 | A | L | Oak Glen | 26 | Indian Creek (OH) | 56 | OVAC Consolation | 1634 | |
| 2022-02-18 | H | L | Oak Glen | 40 | Magnolia | 74 | 1343 | ||
| 2022-02-24 | A | L | Oak Glen | 53 | John Marshall | 55 | 742 | ||
| 2022-03-02 | A | L | Oak Glen | 60 | Wheeling Central | 84 | Sectional | 1748 |