| Date |
|
Score |
|
Score |
|
|
| 2008-10-09 | John Adams (OH) | 42 | Marshall (OH) ** | 12 | | |
| 2008-10-10 | Big Creek ** | 44 | St. Paul (VA) | 14 | | |
| 2008-10-10 | Bishop Donahue ** | 20 | Doddridge County | 13 | | |
| 2008-10-10 | Cameron ** | 48 | Hundred | 19 | | |
| 2008-10-10 | Clay-Battelle | 35 | Valley-Wetzel ** | 6 | | |
| 2008-10-10 | Fayetteville ** | 45 | Parkersburg Catholic | 28 | | |
| 2008-10-10 | Gilmer County | 39 | Hannan ** | 6 | | |
| 2008-10-10 | Matewan ** | 48 | Unaka (TN) | 6 | | |
| 2008-10-10 | Meadow Bridge | 69 | Montcalm ** | 40 | | |
| 2008-10-10 | Mt. Hope | 44 | Valley-Fayette ** | 0 | | |
| 2008-10-10 | Pocahontas County ** | 32 | Greenbrier West | 7 | | |
| 2008-10-10 | Richwood ** | 42 | Tygarts Valley | 22 | | |
| 2008-10-10 | South Harrison ** | 33 | Liberty-Harrison | 0 | | |
| 2008-10-10 | St. Marys | 54 | Frontier (OH) ** | 34 | | |
| 2008-10-10 | Tucker County ** | 49 | East Hardy | 19 | | |
| 2008-10-10 | Wahama | 42 | Wirt County ** | 14 | | |
| 2008-10-10 | Chapmanville ** | 28 | Man | 3 | | |
| 2008-10-10 | Grafton | 37 | Williamstown ** | 7 | | |
| 2008-10-10 | Independence ** | 29 | Summers County | 14 | | |
| 2008-10-10 | James Monroe ** | 10 | Narrows (VA) | 6 | | |
| 2008-10-10 | Keyser | 49 | Berkeley Springs ** | 0 | | |
| 2008-10-10 | Lincoln ** | 17 | Ritchie County | 16 | | |
| 2008-10-10 | Magnolia | 31 | Weir ** | 0 | | |
| 2008-10-10 | Oak Glen | 40 | Tyler Consolidated ** | 33 | | |
| 2008-10-10 | Pt. Pleasant ** | 41 | Poca | 12 | | |
| 2008-10-10 | Ravenswood ** | 34 | Braxton County | 0 | | |
| 2008-10-10 | Roane County ** | 61 | Clay County | 16 | | |
| 2008-10-10 | Shady Spring ** | 18 | Sherman | 14 | | |
| 2008-10-10 | Sissonville | 24 | Herbert Hoover ** | 14 | | |
| 2008-10-10 | Webster County | 16 | Oak Hill ** | 12 | | |
| 2008-10-10 | Westside | 33 | PikeView ** | 14 | | |
| 2008-10-10 | Wyoming East ** | 14 | Iaeger | 6 | | |
| 2008-10-10 | Capital | 30 | Greenbrier East ** | 12 | | |
| 2008-10-10 | Elkins ** | 17 | Philip Barbour | 0 | | |
| 2008-10-10 | Fairmont Sr. | 41 | Buckhannon-Upshur ** | 23 | | |
| 2008-10-10 | George Washington ** | 49 | Princeton | 10 | | |
| 2008-10-10 | Hurricane | 26 | Lincoln County ** | 14 | | |
| 2008-10-10 | John Marshall ** | 2 | East Liverpool (OH) | 0 | | |
| 2008-10-10 | Lewis County ** | 39 | Preston | 21 | | |
| 2008-10-10 | Morgantown | 41 | North Marion ** | 0 | | |
| 2008-10-10 | Musselman ** | 54 | Hedgesville | 8 | | |
| 2008-10-10 | Nicholas County | 65 | Liberty-Raleigh ** | 18 | | |
| 2008-10-10 | Parkersburg South | 33 | Parkersburg ** | 14 | | |
| 2008-10-10 | Ripley | 16 | Riverside ** | 14 | | |
| 2008-10-10 | South Charleston ** | 29 | Cabell Midland | 9 | | |
| 2008-10-10 | Spring Valley ** | 38 | Huntington | 35 | | |
| 2008-10-10 | St. Albans ** | 23 | Nitro | 6 | | |
| 2008-10-10 | University ** | 20 | Brooke | 19 | | |
| 2008-10-10 | Washington ** | 19 | Kettle Run (VA) | 0 | | |
| 2008-10-10 | Wheeling Park ** | 43 | Bridgeport | 7 | | |
| 2008-10-10 | Winfield | 34 | Logan ** | 28 | 2 OT | |
| 2008-10-10 | Anacostia (DC) | 2 | Eastern (DC) ** | 0 | | |
| 2008-10-10 | Ballou (DC) ** | 62 | Spingarn (DC) | 6 | | |
| 2008-10-10 | Calvin Coolidge (DC) | 50 | Roosevelt(DC) ** | 10 | | |
| 2008-10-10 | Woodson-Eastern (DC) | 54 | McKinley (DC) ** | 6 | | |
| 2008-10-10 | Berea (KY) ** | 42 | Clinton County (KY) | 18 | | |
| 2008-10-10 | Clark (KY) | 49 | Pike Central (KY) ** | 0 | | |
| 2008-10-10 | Shelby Valley (KY) ** | 48 | Tug Valley | 8 | | |
| 2008-10-10 | Allegany (MD) | 55 | Hampshire ** | 14 | | |
| 2008-10-10 | Boonsboro (MD) ** | 44 | Williamsport (MD) | 6 | | |
| 2008-10-10 | Fort Hill (MD) | 38 | Jefferson ** | 6 | | |
| 2008-10-10 | Frederick (MD) ** | 35 | South Hagerstown (MD) | 0 | | |
| 2008-10-10 | Middletown (MD) ** | 42 | North Hagerstown (MD) | 28 | | |
| 2008-10-10 | Mt. Ridge (MD) | 30 | Northern Garrett County (MD) ** | 0 | | |
| 2008-10-10 | Southern Garrett County (MD) ** | 22 | Petersburg | 0 | | |
| 2008-10-10 | Urbana (MD) | 15 | Johnson (MD) ** | 7 | | |
| 2008-10-10 | Charlotte Country Day Sch (NC) ** | 15 | Crest (NC) | 14 | | |
| 2008-10-10 | Beallsville (OH) | 37 | Bridgeport (OH) ** | 8 | | |
| 2008-10-10 | Chesapeake (OH) ** | 28 | River Valley Cheshire (OH) | 14 | | |
| 2008-10-10 | Columbiana Crestview (OH) | 35 | Mineral Ridge (OH) ** | 0 | | |
| 2008-10-10 | Edison Local (OH) | 35 | Bellaire (OH) ** | 13 | | |
| 2008-10-10 | Gallia Academy (OH) ** | 42 | Wellston (OH) | 20 | | |
| 2008-10-10 | Harrison Central (OH) | 28 | Indian Creek (OH) ** | 11 | | |
| 2008-10-10 | Logan (OH) ** | 42 | Warren Local (OH) | 0 | | |
| 2008-10-10 | Martins Ferry (OH) ** | 34 | St. Clairsville (OH) | 6 | | |
| 2008-10-10 | Monroe Central (OH) ** | 57 | Barnesville (OH) | 6 | | |
| 2008-10-10 | Nelsonville-York (OH) ** | 22 | Athens (OH) | 14 | | |
| 2008-10-10 | Oak Hill (OH) | 56 | Symmes Valley (OH) ** | 7 | | |
| 2008-10-10 | Reedsville Eastern (OH) ** | 49 | Miller (OH) | 34 | | |
| 2008-10-10 | River (OH) ** | 41 | Shenandoah (OH) | 0 | | |
| 2008-10-10 | River View (OH) ** | 37 | Claymont (OH) | 35 | | |
| 2008-10-10 | Sciotoville Community (OH) ** | 31 | South Gallia (OH) | 0 | | |
| 2008-10-10 | Shadyside (OH) ** | 41 | Toronto (OH) | 8 | | |
| 2008-10-10 | Sheridan (OH) ** | 62 | Morgan (OH) | 14 | | |
| 2008-10-10 | South Point (OH) | 39 | Fairland (OH) ** | 34 | | |
| 2008-10-10 | Steubenville (OH) | 39 | Poland Seminary (OH) ** | 20 | | |
| 2008-10-10 | Union Local (OH) ** | 34 | Buckeye Local (OH) | 21 | | |
| 2008-10-10 | Waterford (OH) ** | 15 | Racine Southern (OH) | 7 | | |
| 2008-10-10 | Zanesville (OH) ** | 25 | Marietta (OH) | 14 | | |
| 2008-10-10 | Greencastle Atrium (PA) ** | 35 | Susquehanna Township (PA) | 21 | | |
| 2008-10-10 | Langley (PA) | 21 | Allderdice (PA) ** | 20 | | |
| 2008-10-10 | State College (PA) ** | 51 | Central Dauphin East (PA) | 7 | | |
| 2008-10-10 | Abingdon (VA) | 63 | Grundy (VA) ** | 14 | | |
| 2008-10-10 | Bath County (VA) ** | 46 | Craig County (VA) | 18 | | |
| 2008-10-10 | Bland (VA) ** | 55 | Van | 6 | | |
| 2008-10-10 | Briar Woods (VA) | 17 | Loudoun County (VA) ** | 14 | | |
| 2008-10-10 | Eastern View (VA) ** | 24 | Madison County (VA) | 20 | | |
| 2008-10-10 | Ft. Chiswell (VA) | 33 | Gilbert ** | 0 | | |
| 2008-10-10 | Galax (VA) ** | 30 | Grayson County (VA) | 28 | | |
| 2008-10-10 | Handley (VA) | 23 | Woodstock Central (VA) ** | 6 | | |
| 2008-10-10 | Hurley (VA) ** | 20 | Williamson | 14 | | |
| 2008-10-10 | James Wood (VA) ** | 35 | Brentsville District (VA) | 14 | | |
| 2008-10-10 | Manassas Park (VA) | 27 | Mason (VA) ** | 21 | 2 OT | |
| 2008-10-10 | Potomac Falls (VA) | 28 | Park View-Sterling (VA) ** | 20 | | |
| 2008-10-10 | Pound (VA) ** | 42 | Twin Valley (VA) | 18 | | |
| 2008-10-10 | Sherando (VA) | 44 | Skyline (VA) ** | 20 | | |
| 2008-10-10 | Tazewell (VA) ** | 20 | Graham (VA) | 6 | | |
| 2008-10-10 | Turner Ashby (VA) | 24 | Fort Defiance (VA) ** | 13 | | |
| 2008-10-11 | Madonna | 57 | Notre Dame ** | 7 | | |
| 2008-10-11 | Moorefield | 54 | Rappahannock County (VA) ** | 6 | | |
| 2008-10-11 | Wheeling Central ** | 42 | Schenley (PA) | 26 | | |
| 2008-10-11 | Bluefield ** | 35 | Richlands (VA) | 14 | | |
| 2008-10-11 | Friendship Collegiate (DC) ** | 38 | Fairmont Heights (MD) | 0 | | |
| 2008-10-11 | Bishop Rosecrans (OH) | 46 | Bellaire St.John (OH) ** | 7 | | |
| 2008-10-11 | FCI Academy (OH) | 31 | Steubenville Central (OH) ** | 20 | | |
| 2008-10-11 | Green (OH) | 36 | Portsmouth Notre Dame (OH) ** | 12 | | |
| 2008-10-11 | University (OH) ** | 28 | Warren JFK (OH) | 17 | | |
| 2008-10-11 | Brashear (PA) ** | 54 | Peabody (PA) | 22 | | |
| 2008-10-11 | Carrick (PA) ** | 18 | Oliver (PA) | 12 | | |
| 2008-10-11 | Ferndale (PA) ** | 12 | Hancock (MD) | 0 | | |
| 2008-10-11 | Linsly (WV) ** | 40 | Buckeye Trail (OH) | 0 | | |
| 2008-10-13 | Roanoke Catholic (VA) ** | 53 | Montcalm | 0 | | |