| Date |
|
Score |
|
Score |
|
|
| 2008-10-30 | Madonna | 43 | Bishop Donahue ** | 0 | | |
| 2008-10-30 | Shady Spring ** | 60 | Liberty-Raleigh | 6 | | |
| 2008-10-31 | Big Creek | 43 | Burch ** | 6 | | |
| 2008-10-31 | Calhoun County ** | 46 | Braxton County | 13 | | |
| 2008-10-31 | East Hardy ** | 42 | Cameron | 41 | | |
| 2008-10-31 | Fayetteville ** | 48 | Greenbrier West | 21 | | |
| 2008-10-31 | Gilbert ** | 34 | Wirt County | 19 | | |
| 2008-10-31 | Man ** | 14 | Buffalo | 6 | | |
| 2008-10-31 | Matewan ** | 57 | Mt. View | 12 | | |
| 2008-10-31 | Midland Trail | 37 | Valley-Fayette ** | 12 | | |
| 2008-10-31 | Montcalm ** | 31 | Hannan | 24 | | |
| 2008-10-31 | Moorefield | 22 | Pendleton County ** | 14 | | |
| 2008-10-31 | Mt. Hope | 58 | Meadow Bridge ** | 23 | | |
| 2008-10-31 | Paden City | 22 | Valley-Wetzel ** | 14 | | |
| 2008-10-31 | Pocahontas County | 56 | Webster County ** | 13 | | |
| 2008-10-31 | South Harrison | 28 | Lincoln ** | 21 | | |
| 2008-10-31 | St. Marys ** | 54 | Doddridge County | 13 | | |
| 2008-10-31 | Tucker County | 52 | Petersburg ** | 8 | | |
| 2008-10-31 | Tygarts Valley ** | 26 | Hundred | 14 | | |
| 2008-10-31 | Wheeling Central ** | 49 | Linsly (WV) | 20 | | |
| 2008-10-31 | Williamstown | 59 | Ritchie County ** | 0 | | |
| 2008-10-31 | Berkeley Springs ** | 10 | Manassas Park (VA) | 7 | | |
| 2008-10-31 | Bluefield | 34 | James Monroe ** | 21 | | |
| 2008-10-31 | Grafton | 54 | Liberty-Harrison ** | 7 | | |
| 2008-10-31 | Independence | 37 | Wyoming East ** | 6 | | |
| 2008-10-31 | Keyser | 61 | Frankfort ** | 8 | | |
| 2008-10-31 | Magnolia | 42 | Oak Glen ** | 23 | | |
| 2008-10-31 | Oak Hill | 19 | PikeView ** | 18 | | |
| 2008-10-31 | Pt. Pleasant | 41 | Herbert Hoover ** | 15 | | |
| 2008-10-31 | Ravenswood | 49 | Logan ** | 20 | | |
| 2008-10-31 | Scott | 25 | Sherman ** | 13 | | |
| 2008-10-31 | Sissonville | 48 | Poca ** | 28 | | |
| 2008-10-31 | Summers County ** | 46 | Richwood | 14 | | |
| 2008-10-31 | Tolsia | 24 | Winfield ** | 21 | | |
| 2008-10-31 | Tug Valley | 50 | Williamson ** | 18 | | |
| 2008-10-31 | Tyler Consolidated ** | 54 | Clay County | 7 | | |
| 2008-10-31 | Wayne | 25 | Chapmanville ** | 13 | | |
| 2008-10-31 | Weir | 28 | Brooke ** | 27 | | |
| 2008-10-31 | Westside | 33 | Iaeger ** | 20 | | |
| 2008-10-31 | Bridgeport | 28 | Fairmont Sr. ** | 21 | | |
| 2008-10-31 | Cabell Midland | 28 | St. Albans ** | 13 | | |
| 2008-10-31 | Capital ** | 37 | Riverside | 3 | | |
| 2008-10-31 | George Washington | 42 | Woodrow Wilson ** | 12 | | |
| 2008-10-31 | Greenbrier East | 24 | Princeton ** | 17 | | |
| 2008-10-31 | Hampshire | 14 | Washington ** | 12 | | |
| 2008-10-31 | Huntington ** | 35 | Nitro | 20 | | |
| 2008-10-31 | Jefferson ** | 33 | Greencastle Atrium (PA) | 27 | | |
| 2008-10-31 | Martinsburg ** | 36 | Musselman | 7 | | |
| 2008-10-31 | Morgantown ** | 27 | University | 14 | | |
| 2008-10-31 | North Marion ** | 36 | Elkins | 35 | 1 OT | |
| 2008-10-31 | Parkersburg | 24 | Ripley ** | 23 | | |
| 2008-10-31 | Parkersburg South ** | 22 | East Fairmont | 13 | | |
| 2008-10-31 | Preston ** | 35 | Buckhannon-Upshur | 20 | | |
| 2008-10-31 | Robert C. Byrd | 24 | Lewis County ** | 18 | | |
| 2008-10-31 | Spring Valley | 20 | Hurricane ** | 19 | | |
| 2008-10-31 | Wheeling Park | 60 | John Marshall ** | 3 | | |
| 2008-10-31 | Dunbar (DC) ** | 34 | Calvin Coolidge (DC) | 27 | | |
| 2008-10-31 | Friendship Collegiate (DC) ** | 42 | Roosevelt(DC) | 6 | | |
| 2008-10-31 | Spingarn (DC) ** | 24 | McKinley (DC) | 19 | | |
| 2008-10-31 | Woodson-Eastern (DC) | 36 | Anacostia (DC) ** | 0 | | |
| 2008-10-31 | Jenkins (KY) | 26 | Betsy Layne (KY) ** | 0 | | |
| 2008-10-31 | Paintsville (KY) ** | 12 | Pike Central (KY) | 7 | | |
| 2008-10-31 | Powell County (KY) ** | 21 | Berea (KY) | 20 | | |
| 2008-10-31 | Prestonsburg (KY) | 13 | Shelby Valley (KY) ** | 12 | | |
| 2008-10-31 | Allegany (MD) ** | 45 | Northern Garrett County (MD) | 16 | | |
| 2008-10-31 | Boonsboro (MD) ** | 38 | Catoctin (MD) | 22 | | |
| 2008-10-31 | North Hagerstown (MD) ** | 31 | Frederick (MD) | 29 | | |
| 2008-10-31 | South Hagerstown (MD) | 27 | Walkersville (MD) ** | 23 | | |
| 2008-10-31 | Urbana (MD) ** | 34 | North Carroll (MD) | 7 | | |
| 2008-10-31 | Charlotte Latin (NC) | 30 | Charlotte Country Day Sch (NC) ** | 10 | | |
| 2008-10-31 | State College (PA) ** | 38 | Chambersburg (PA) | 3 | | |
| 2008-10-31 | Unaka (TN) | 18 | Jellico (TN) ** | 17 | | |
| 2008-10-31 | Bath County (VA) ** | 12 | James River (VA) | 7 | | |
| 2008-10-31 | Bland (VA) ** | 26 | Ft. Chiswell (VA) | 6 | | |
| 2008-10-31 | Brentsville District (VA) ** | 47 | Woodstock Central (VA) | 20 | | |
| 2008-10-31 | Carroll County (VA) ** | 47 | Graham (VA) | 6 | | |
| 2008-10-31 | Eastern View (VA) ** | 34 | Kettle Run (VA) | 0 | | |
| 2008-10-31 | Handley (VA) | 17 | James Wood (VA) ** | 10 | | |
| 2008-10-31 | Heritage (VA) ** | 41 | Park View-Sterling (VA) | 14 | | |
| 2008-10-31 | Hurley (VA) ** | 26 | Twin Valley (VA) | 16 | | |
| 2008-10-31 | Loudoun County (VA) ** | 26 | Dominion (VA) | 6 | | |
| 2008-10-31 | McCluer (VA) | 39 | Craig County (VA) ** | 22 | | |
| 2008-10-31 | Millbrook (VA) ** | 24 | Sherando (VA) | 17 | | |
| 2008-10-31 | Narrows (VA) ** | 27 | Galax (VA) | 8 | | |
| 2008-10-31 | North Cross (VA) | 27 | Roanoke Catholic (VA) ** | 13 | | |
| 2008-10-31 | Potomac Falls (VA) | 42 | Briar Woods (VA) ** | 27 | | |
| 2008-10-31 | Richlands (VA) | 49 | Grundy (VA) ** | 13 | | |
| 2008-10-31 | Turner Ashby (VA) ** | 41 | Broadway (VA) | 7 | | |
| 2008-10-31 | Walker (VA) | 34 | St. Paul (VA) ** | 20 | | |
| 2008-11-01 | Clay-Battelle | 29 | Notre Dame ** | 12 | | |
| 2008-11-01 | Parkersburg Catholic ** | 37 | Wahama | 34 | | |
| 2008-11-01 | Bishop Walsh (MD) ** | 20 | Southern Garrett County (MD) | 6 | | |
| 2008-11-01 | Fort Hill (MD) ** | 22 | Mt. Ridge (MD) | 6 | | |