| Date |
|
Score |
|
Score |
|
|
| 2021-11-01 | Liberty-Raleigh ** | 1 | PikeView | 0 | | |
| 2021-11-01 | Bridgeport ** | 1 | Parkersburg South | 0 | | |
| 2021-11-02 | James Monroe | 35 | Covington (VA) ** | 16 | | |
| 2021-11-02 | Valley-Wetzel ** | 52 | Hundred | 22 | | |
| 2021-11-02 | Shady Spring | 40 | PikeView ** | 26 | | |
| 2021-11-02 | Bath County (VA) ** | 19 | Craig County (VA) | 10 | | |
| 2021-11-02 | Salem (VA) | 1 | Blacksburg (VA) ** | 0 | | |
| 2021-11-02 | Tazewell (VA) | 41 | John S. Battle (VA) ** | 18 | | |
| 2021-11-03 | Twin Valley (VA) ** | 50 | Honaker (VA) | 36 | | |
| 2021-11-04 | Wheeling Central | 55 | Oak Glen ** | 17 | | |
| 2021-11-04 | Graham (VA) ** | 49 | Marion (VA) | 14 | | |
| 2021-11-05 | Buffalo ** | 20 | Wahama | 14 | | |
| 2021-11-05 | Clay-Battelle | 58 | Hundred ** | 0 | | |
| 2021-11-05 | Doddridge County | 34 | Tygarts Valley ** | 0 | | |
| 2021-11-05 | East Hardy | 28 | Petersburg ** | 0 | | |
| 2021-11-05 | James Monroe ** | 32 | Summers County | 6 | | |
| 2021-11-05 | Meadow Bridge ** | 24 | Gilmer County | 14 | | |
| 2021-11-05 | Midland Trail ** | 42 | Pocahontas County | 6 | | |
| 2021-11-05 | Mt. View | 18 | Greenbrier West ** | 14 | | |
| 2021-11-05 | Richwood ** | 38 | River View | 34 | | |
| 2021-11-05 | Ritchie County | 45 | Calhoun County ** | 20 | | |
| 2021-11-05 | Sherman ** | 48 | Wirt County | 34 | | |
| 2021-11-05 | South Harrison | 36 | Tucker County ** | 24 | | |
| 2021-11-05 | St. Marys ** | 36 | Tyler Consolidated | 16 | | |
| 2021-11-05 | Trinity ** | 31 | Madonna | 14 | | |
| 2021-11-05 | Tug Valley ** | 42 | Van | 20 | | |
| 2021-11-05 | Valley-Wetzel | 46 | Paden City ** | 20 | | |
| 2021-11-05 | Webster County ** | 41 | Montcalm | 20 | | |
| 2021-11-05 | Williamstown ** | 53 | Magnolia | 6 | | |
| 2021-11-05 | Berkeley Springs | 40 | Moorefield ** | 13 | | |
| 2021-11-05 | Bluefield ** | 55 | Mingo Central | 6 | | |
| 2021-11-05 | Chapmanville Regional ** | 40 | Man | 28 | | |
| 2021-11-05 | Clay County ** | 61 | Braxton County | 27 | | |
| 2021-11-05 | Fairmont Sr. | 26 | East Fairmont ** | 7 | | |
| 2021-11-05 | Frankfort | 41 | Keyser ** | 35 | | |
| 2021-11-05 | Grafton ** | 48 | Lewis County | 6 | | |
| 2021-11-05 | Herbert Hoover ** | 48 | Logan | 6 | | |
| 2021-11-05 | Liberty-Raleigh | 54 | Wyoming East ** | 6 | | |
| 2021-11-05 | Nicholas County ** | 54 | PikeView | 14 | | |
| 2021-11-05 | North Marion ** | 55 | Liberty-Harrison | 0 | | |
| 2021-11-05 | Pt. Pleasant | 17 | Winfield ** | 14 | | |
| 2021-11-05 | Roane County ** | 58 | Sissonville | 40 | | |
| 2021-11-05 | Robert C. Byrd | 57 | Philip Barbour ** | 6 | | |
| 2021-11-05 | Scott | 22 | Nitro ** | 18 | | |
| 2021-11-05 | Wayne ** | 26 | Poca | 20 | | |
| 2021-11-05 | Bridgeport | 38 | Lincoln ** | 7 | | |
| 2021-11-05 | Brooke ** | 14 | Preston | 7 | | |
| 2021-11-05 | Buckhannon-Upshur | 33 | Elkins ** | 6 | | |
| 2021-11-05 | Cabell Midland | 55 | St. Albans ** | 0 | | |
| 2021-11-05 | George Washington ** | 41 | Capital | 0 | | |
| 2021-11-05 | Greenbrier East ** | 61 | Lincoln County | 22 | | |
| 2021-11-05 | Huntington | 49 | Riverside ** | 7 | | |
| 2021-11-05 | Jefferson | 47 | Washington ** | 13 | | |
| 2021-11-05 | Morgantown | 49 | Spring Mills ** | 13 | | |
| 2021-11-05 | Parkersburg | 56 | Musselman ** | 52 | | |
| 2021-11-05 | Parkersburg South ** | 44 | Princeton | 34 | | |
| 2021-11-05 | Spring Valley ** | 21 | Hurricane | 7 | | |
| 2021-11-05 | University ** | 63 | Oak Hill | 21 | | |
| 2021-11-05 | Wheeling Park | 35 | John Marshall ** | 7 | | |
| 2021-11-05 | Woodrow Wilson | 42 | South Charleston ** | 21 | | |
| 2021-11-05 | Armstrong (VA) | 20 | Park View-Sterling (VA) ** | 14 | | |
| 2021-11-05 | Covington (VA) ** | 28 | Craig County (VA) | 14 | | |
| 2021-11-05 | Eastern View (VA) ** | 52 | Millbrook (VA) | 42 | | |
| 2021-11-05 | Handley (VA) | 26 | James Wood (VA) ** | 14 | | |
| 2021-11-05 | Kettle Run (VA) | 57 | Sherando (VA) ** | 35 | | |
| 2021-11-05 | Narrows (VA) | 56 | Bath County (VA) ** | 0 | | |
| 2021-11-05 | Ridgeview (VA) ** | 48 | Gate City (VA) | 7 | | |
| 2021-11-05 | Roanoke Catholic (VA) | 58 | Massanutten Mil. Acad. (VA) ** | 36 | | |
| 2021-11-05 | Salem (VA) ** | 37 | Patrick Henry - Roanoke (VA) | 13 | | |
| 2021-11-05 | Skyline (VA) | 13 | Warren County (VA) ** | 7 | | |
| 2021-11-06 | Hedgesville | 34 | Hampshire ** | 21 | | |
| 2021-11-06 | Twin Valley (VA) | 34 | Hurley (VA) ** | 28 | | |
| 2021-11-06 | Varina (VA) | 7 | Highland Springs (VA) ** | 6 | | |