| Date |
|
Score |
|
Score |
|
|
| 2022-11-10 | East Hardy | 34 | Tucker County ** | 6 | | 7-10 1st RD Playoffs |
| 2022-11-10 | Herbert Hoover | 63 | Clay County ** | 26 | | 8-9 1st RD Playoffs |
| 2022-11-10 | Wheeling Park | 23 | Musselman ** | 28 | | 8-9 1st RD Playoffs |
| 2022-11-11 | Doddridge County | 43 | Van ** | 0 | | 6-11 1st RD Playoffs |
| 2022-11-11 | South Harrison | 0 | Greenbrier West ** | 35 | | 8-9 1st RD Playoffs |
| 2022-11-11 | Tyler Consolidated | 6 | Cameron ** | 20 | | 3-14 1st RD Playoffs |
| 2022-11-11 | Bluefield | 12 | Independence ** | 20 | | 2-15 1st RD Playoffs |
| 2022-11-11 | Chapmanville Regional | 20 | Fairmont Sr. ** | 42 | | 7-10 1st RD Playoffs |
| 2022-11-11 | East Fairmont | 31 | Scott ** | 35 | | 4-13 1st RD Playoffs |
| 2022-11-11 | Lincoln | 7 | North Marion ** | 37 | | 6-11 1st RD Playoffs |
| 2022-11-11 | Nicholas County | 0 | Frankfort ** | 14 | | 5-12 1st RD Playoffs |
| 2022-11-11 | Morgantown | 14 | Martinsburg ** | 42 | | 3-14 1st RD Playoffs |
| 2022-11-11 | Princeton | 28 | George Washington ** | 31 | | 5-12 1st RD Playoffs |
| 2022-11-11 | University | 12 | Hurricane ** | 56 | | 4-13 1st RD Playoffs |
| 2022-11-11 | Woodrow Wilson | 22 | Huntington ** | 62 | | 2-15 1st RD Playoffs |
| 2022-11-12 | Clay-Battelle | 6 | Williamstown ** | 49 | | 2-15 1st RD Playoffs @Parkersburg |
| 2022-11-12 | Man | 0 | Wheeling Central ** | 41 | | 5-12 1st RD Playoffs @Wheeling Univ. |
| 2022-11-12 | Petersburg | 13 | James Monroe ** | 37 | | 1-16 1st RD Playoffs |
| 2022-11-12 | St. Marys | 21 | Wahama ** | 52 | | 4-13 1st RD Playoffs @Pt. Pleasant |
| 2022-11-12 | Logan | 0 | Winfield ** | 43 | | 1-16 1st RD Playoffs |
| 2022-11-12 | Weir | 20 | Roane County ** | 40 | | 3-14 1st RD Playoffs |
| 2022-11-12 | Cabell Midland | 13 | Bridgeport ** | 41 | | 6-11 1st RD Playoffs |
| 2022-11-12 | Hedgesville | 12 | Parkersburg South ** | 78 | | 1-16 1st RD Playoffs |
| 2022-11-12 | Jefferson | 34 | Spring Valley ** | 14 | | 7-10 1st RD Playoffs |